|
PRELIMINAR PROGRAM
|
NOVEMBER 3rd , 2013 |
14h00
17h00 |
Meeting Registration |
18h30
20h30 |
Opening Cerimony
OPENING CONFERENCE
PROGRESS AND CHALLENGES TOWARDS THE CONTROL AND ELIMINATION OF NEGLECTED TROPICAL DISEASES IN LATIN AMERICA AND THE CARIBBEAN: A VIEW FROM THE PAN AMERICAN HEALTH ORGANIZATION
Room 1
Chair: Denise V. Tambourgi (Brazil)
Speaker: Ruben Santiago Nicholls (Pan American Health Organization/WHO) |
20h30 |
WELCOME RECEPTION |
|
|
NOVEMBER 4th, 2013 |
|
Room 1 |
Room 2 |
Room 3 |
08h40
09h30 |
CONFERENCE #1
OVERVIEW OF CLINICAL FEATURES AND THERAPY OF SNAKE-BITE ENVENOMING IN THE AMERICAS
Chair: Julia Prado Franceschi (Brazil)
Speaker: David Warrell (UK) |
|
|
09h30
10h00 |
COFFEE BREAK |
10h00
12h00 |
SESSION # 1: INTEGRATIVE TOXINOLOGY
Room 1
Chairs:
1- Solange Serrano (Brazil)
2- Carlos Sevcik (Venezuela)
Speakers:
-
Stephen Mackessy (USA) “Effects of positive selection on structure/function evolution of colubrid three-finger toxins: coevolutionary adjustments?”
-
Carlos Sevcik (Venezuela) “Characterizing venoms from a fractal perspective”
-
Inácio Junqueira de Azevedo (Brazil) “Combining transcriptomics, proteomics and functional characterization to a better knowledge of colubrid venoms”
-
André Pereira P. Zelanis (Brazil) “Systemic approaches in Toxinology: perspectives and implications of omics methodologies on the study of snake venom toxins”
-
Hugo Vigerelli (Brazil) “Antiviral effects of alkaloids and steroids from Rhinella jimi skin secretion on rabies virus infection in BHK-21 cell line”
|
SESSION # 2: CLINICAL ASPECTS OF SNAKE ENVENOMATION
Chairs:
1- Fan Hui Wen (Brazil)
2- Abdulrazaq G. Habiib (Nigeria)
Speakers:
-
Fan Hui Wen (Brazil) “Clinical Toxinolgy in a globalized world”
-
Abdulrazaq G. Habiib (Nigeria) “Overview of clinical features and therapy of snakebite envenoming”
-
Marcus V. G. Lacerda (Brazil) “Snakebites in the State of Amazonas: a preliminary analysis of a largely neglected problem”
-
Steven Seifert (USA) “A new dosing regimen for a Fab antivenom in rattlesnake bite with recurrent venom effects”
-
Ceila Maria Sant’Ana Malaque (Brazil) “Acute kidney injury (AKI) secondary to Bothrops spp. snake bites in patients treated in Vital Brazil Hospital (VBH), Butantan Institute, São Paulo”
|
SESSION # 3: MARINE TOXINS
Chairs:
1- Frank Mari (USA)
2- P. Gopalakrishnakone (Singapore)
Speakers:
-
Frank Mari (USA) “Adventures with marine toxins from the Americas: the discovery of Conotoxin structures and their functional implications”
-
María E. Lanio (Cuba) “Novel approaches for nanobiotech applications of Sticholysins, two pore-forming toxins”
-
Miriam Camargo Guarnieri (Brazil) “Pharmacological characterization of the mucus of zoanthid Palythoa caribaeorum (Cnidaria, Anthozoa) from Northeastern Brazil”
-
Katsuhiro Konno (Japan) “Novel peptide toxins with two disulfide bridges from the venom of the Brazilian sea anemone Bunodosoma cangicum”
-
Mariela Álvarez Álvarez Cárdenas (Mexico) “Identification of non-protein hemolytic compounds in the venom of the fire coral Millepora complanata”
|
13h30
14h30 |
CONFERENCE #2: VENOMICS OF SNAKES FROM THE AMERICAS
Chair: Jonas Perales (Brazil)
Speaker: Juan Calvete (Spain) |
|
|
14h30
15h00 |
COFFEE BREAK |
15h00
17h00 |
SESSION # 4: TOXIN PROTEOMICS
Chairs:
1- Gilberto Domont (Brazil)
2- Bruno Lomonte (Costa Rica)
Speakers:
1. Gilberto Domont (Brazil) "Discovery driven-venomics: poisons of Brazilian rattle and coral snakes"
2. Bruno Lomonte (Costa Rica) “Venomous snakes of Costa Rica: taxonomical, biological, and clinical implications of their proteomic profiling through the strategy of snake venomics"
3. Mario Sérgio Palma (Brazil) “Proteomics as experimental strategy for proofing the functional targets of mastoparan peptides”
4. Alexandre K. Tashima (Brazil) “Venom peptidomics of the Brazilian spider Acanthoscurria gomesiana”
5. Juliana Silva Cassoli (Brazil) “The proteomic profile of Stichodactyla duerdeni secretion reveals the presence of a novel o-linked glycopeptide” |
SESSION # 5: TOXINS AND ION CHANNELS
Chairs:
1- Paulo Sérgio Beirão (Brazil)
2- Jan Tytgat (Belgium)
Speakers:
-
Jan Tytgat (Belgium) “Cone snail venom peptides: an inexhaustible treasury for drug leads”
-
Paulo Sérgio Beirão (Brazil) "How sodium channels are modified by Phoneutria nigriventer toxins”
-
Frank Bosmans (USA) “μ-Diguetoxin-Dc1a promotes BgNav1 opening by influencing the domain II voltage sensor”
-
Steve Peigneur (Belgium) “When cone snails and spiders meet: design of selective and potent sodium channel inhibitors”
-
Harry Morales (Brazil) “New K+- channels blockers from the Tityus sp venom gland”
|
SESSION # 6: TOXINS FROM MICROBES
Chairs:
1- Celia Carlini (Brazil)
2- Wilmar Dias da Silva (Brazil)
Speakers:
-
Wilmar Dias da Silva (Brazil) “Development of recombinant Bacillus Calmette Guerin (BCG) and M. smegmatis expressing Escherichia coli BFPA and intimin virulence genes”
-
Jorge Kalil (Brazil) “How M protein from Streptoccoccus causes human diseases”
-
Celia Carlini (Brazil) “Ureases are multifunctional toxins”
-
Walter A. Zin (Brazil) “Cellular and systemic pulmonary alterations induced by cyanotoxins”
-
Davi Felipe Farias (Brazil) “Effects of CRY8KA5 mutant entomotoxin on gene expression profile of MCF-7 and CACO-2 human cancer cell lines”
|
17h00
19h00 |
Poster session 1 (ROOM 4) |
18h30
20h00 |
GENERAL MEETING – IST |
20h00 |
SBTX JOVEM – HAPPY HOUR |
|
|
NOVEMBER 5th, 2013 |
|
Room 1 |
Room 2 |
Room 3 |
08h40
09h30 |
CONFERENCE #3
SNAKE VENOM PROTEINASES DEGRADOMICS: TOWARDS UNDERSTANDING THEIR EFFECTS UPON HUMAN PLATELETS AND PLASMA, AND MOUSE SKIN
Chair: Gilberto Domont (Brazil)
Speaker: Solange M. T. Serrano (Brazil) |
|
|
09h30
10h00 |
COFFEE BREAK |
10h00
12h00 |
SESSION # 7: ANTIVENOMS
Room 1
Chairs:
1- Jorge Kalil (Brazil)
2- José María Gutiérrez (Costa Rica)
Speakers:
-
José María Gutiérrez (Costa Rica) “New antivenoms for sub-Saharan Africa: Key issues related to their design and evaluation”
-
Carlos Sevcik (Venezuela) “Pharmacokinetics of antivenoms (AV), models versus the real thing: A high resolution fluorescence microscopy approach”
-
Carla Cristina Squaiella Baptistão (Brazil) “Anticomplementary activity of horse IgG and F(ab’)2 antivenoms”
-
Carlos Chávez Olortegui (Brazil) “Perspectives for the production of new antivenoms against Loxosceles spp. spiders using a recombinant chimeric protein”
-
Leandro Soares Moreira Dill (Brazil) “Antibodies produced against native and modified Phospholipases A2: analysis of antigen-antibody and cross-reactivity interactions by surface plasmon resonance”
|
SESSION # 8: STRUCTURE AND FUNCTION OF TOXINS
Room 2
Chairs:
1- Marcos R. M. Fontes (Brazil)
2- Carlos Alvarez Valcárcel (Cuba)
Speakers:
-
Marcos R. M. Fontes (Brazil) “Proposition of novel comprehensive model for myotoxic activity on bothropic phospholipases A2”
-
Carlos Alvarez Valcárcel (Cuba) “Crosstalk between the pore-forming toxins Sticholysins and membranes”
-
Ana Gisele C. Neves-Ferreira (Brazil) “A comparative study on the inhibitory specificities of the antitoxins DM43 and BJ46A: focus on the catalytic domain of snake venom metalloproteinases“
-
Muhamad R. A. Rusmili (Australia) “Isolation and pharmacological characterization of a novel short neurotoxin, α-elapidtoxin-Bf1b from Malaysian Bungarus fasciatus”
-
Carlos Alexandre Fernandes (Brazil) “Structural studies with two lys49-PLA2s isolated from Bothrops brazili venom reveals a new mechanism of action from Lys49-PlA2s from snakes of Bothrops genus”
|
SESSION # 9: TOXINS AND INHIBITORS
Chairs:
1- Consuelo Latorre Fortes Dias (Brazil)
2- Jonas Perales (Brazil)
Speakers:
-
Consuelo Latorre Fortes Dias (Brazil) “Inhibitors of Phospholipases A2 in the blood plasma of Brazilian snakes”
-
Jonas Perales (Brazil) “NATURAL INHIBITORS OF SNAKE VENOM TOXINS: STATE OF THE ART AND PERSPECTIVES”
-
Paulo Melo (Brazil) “Ability of some natural and synthetic substances to antagonize toxins”
-
Fabio Rogério de Moraes (Brazil) “Binding affinities comparison of snake venom serine proteinases and natural inhibitors”
-
Juliana Izabel dos Santos (Brazil) “Structural bases of snake venom metalloproteinases inhibition by triacontyl p-coumarate”
|
13h30
14h30 |
CONFERENCE #4
SNAKE VENOM PROTEINS AFFECTING PLATELET RECEPTOR FUNCTION
Chair: Ana Marisa Chudzinski Tavassi (Brazil)
Speaker: Kenneth J. Clemetson (Switzerland) |
|
|
14h30
15h00 |
COFFEE BREAK |
15h00
17h00 |
SESSION # 10: TOXINS AND HAEMOSTASIS
Chairs:
1- Russolina B. Zingali (Brazil)
2- R. Manjunatha Kini (Singapore)
Speakers:
-
R. Manjunatha Kini (Singapore) “Toxins in thrombosis and hemostasis”
-
Russolina B. Zingali (Brazil) “Antithrombotic agents isolated from venoms and bacteria”
-
Ivo Francischetti (USA) “Antihemostatics from blood-sucking arthropods”
-
Jeilyn D. Vivas (Venezuela) “A novel plasmin inhibitor (Tenerplasminin) isolated from Micrurus tener tener venom”
|
SESSION # 11: ARTHROPODS ENVENOMATION AND THERAPEUTICS
Chairs:
1-Mario Sérgio Palma (Brazil)
2- Julian White (Australia)
Speakers:
-
Julian White (Australia) “Treating arthropod envenoming: do we have a clearly appropriate management strategy?”
-
Fábio Bucaretchi (Brazil) “Envenomation caused by wandering spiders (Phoneutria spp)”
-
Ceila Malaque Sant'Ana (Brazil) “Loxoscelism: how to evaluate the safety and efficacy of antivenom in clinical practice?”
-
Paulo Assis Melo (Brazil) “Effects the treatment with capsaicin or eugenol in the activities of Apis mellifera venom in mice”
-
Jimmy Alexander Guerrero-Vargas (Colombia) “Scorpionism in Colombia”
|
SESSION # 12: TOXINS AND EVOLUTION
Chairs
1- Inácio Junqueira de Azevedo (Brazil)
2- H. Lisle Gibbs (USA)
Speakers:
-
H. Lisle Gibbs (USA) “Phylogeny-based comparative analysis of venom proteome variation in a clade of rattlesnakes (Sistrurus sp)”
-
Inácio Junqueira de Azevedo (Brazil) “Snake toxin genes origins and evolution in the light of toxin-related genes background”
-
Aurélio Pedroso (Brazil) “Phylogenetic analysis of Sphingomyelinase D and evolution of the presence of disulfide bridges”
-
Guilherme H. M. Salvador (Brazil) “Structural and phylogenetic studies with MJTX-I reveal a multi-oligomeric toxin – a novel feature in Lys49-PLA2s protein class”
-
Caroline B. F. Mourão (Brazil) “Protease inhibitors from venomous animals”
|
17h00
19h00 |
Poster session 2 |
18h30
20h00 |
GENERAL MEETING – SBTx |
|
|
NOVEMBER 6th, 2013 |
|
Room 1 |
Room 2 |
Room 3 |
08h40
09h30 |
CONFERENCE #5
THE ROLE OF DAMAGE ASSOCIATED MOLECULAR PATTERN (DAMPS) PROTEINS IN SNAKE VENOM PATHOPHYSIOLOGY (CANCELED)
Chair: Solange M. T. Serrano (Brazil)
Speaker: Jay Fox (USA) |
|
|
09h30
10h00 |
COFFEE BREAK |
10h00
12h00 |
SESSION # 13: TOXINS AND INFLAMMATION
Chairs:
1- Catarina Teixeira (Brazil)
2- Thereza Christina
Barja Fidalgo (Brazil)
Speakers:
-
Catarina Teixeira (Brazil) “Lipid droplet formation induced by MT-III, a phospholipase A2 isolated from Bothrops asper snake venom in macrophages, involves major phospholipid metabolism regulators and engagement of TLR2 via MYD88”
-
Thereza Christina Barja Fidalgo (Brazil) “Proinflammatory response of vascular cells to toxins: the early beginning of everything”
-
Jay Fox (USA) “Proteomics of wound blisters in humans caused by snake envenomation” (CANCELED)
-
Sandra Coccuzo (Brazil) “Modulatory action of Crotoxin on events involved in the tumor progression. In vitro assay”
-
Iara Camargo Lima (Brazil) “Effects of Jararhagin-C (Jar-C), a disintegrin-like molecule from Bothrops jararaca venom, on human endothelial cells adhered to collagen”
|
SESSION # 14: DRUG DESIGN BASED ON VENOM COMPONENTS
Chairs:
1- Ana Marisa Chudzinski Tavassi (Brazil)
2- Carl W. Vogel (USA)
Speakers:
-
Ana Marisa Chudzinski Tavassi (Brazil) “Amblyomin-X: development of a factor Xa inhibitor as a new antitumor molecule”
-
Carl W. Vogel (USA) “Intelligent drug design from a venom component: humanized Cobra Venom Factor for immunotherapy of diseases with complement pathogenesis”
-
P. Gopalakrishnakone (Singapore) “Pip Peptides: Novel Leads for Treatment of Inflammation Relating to PlA2”
-
Kerly Fernanda Mesquita Pasqualoto (Brazil) “Exploring peptide derivatives from lipocalin family as potential hits on coagulation and cell targets”
-
Andreia Biolchi Mayer (Brazil) “Identification of peptides from the venom of the wasp Parachartergus fraternus with neuroprotective activity in a murine model of Parkinson's disease”
|
SESSION # 15: EDUCATION AND SCIENCE DIFFUSION IN TOXINOLOGY
Chairs:
1- Norma Yamanouye (Brazil)
2- Julian White (Australia)
Speakers:
-
Norma Yamanouye (Brazil) “The Post-graduation Program in Toxinology”
-
Julian White (Australia) “New developments in clinical Toxinology education and training”
-
Martha Marandino (Brazil) “Education and Science Diffusion in Toxinology”
-
Rejane Maria Lira da Silva (Brazil) “Panorama of Education on Poisonous Animals in Training of Doctors and Biologists at Federal Institutions of Higher Education in Brazil”
- Manoel Santana Cardoso (Brazil) “CAPES actions in Toxinology”
|
12h00
13h00 |
SBTx JOVEM MEETING |
|
|
|
FREE AFTERNOON |
|
|
NOVEMBER 7th, 2013 |
|
Room 1 |
Room 2 |
Room 3 |
08h40
09h30 |
CONFERENCE #6
SCORPION VENOM COMPONENTS
Chair: Paulo Sérgio Beirão (Brazil)
Speaker: Lourival Possani (Mexico) |
|
|
09h30
10h00 |
COFFEE BREAK |
10h00
12h00 |
SESSION # 16: SCORPION TOXINS
Chairs:
1- Lucia Helena Faccioli (Brazil)
2- Lourival Possani (Mexico)
Speakers:
-
Lucia Helena Facioli (Brazil) “CD14, TLR2 and TLR4 are essential to macrophages recognize Tityus serrulatus venom and its toxin 1 and to release lipid mediators, IL-6 and TNFα”
-
Gina D’Suze (Venezuela) “Macrophage activation by inflammatory toxins isolated from Tityus discrepans scorpion venom. The role of Na+/Ca2+exchangers”
-
Fernanda C.V. Portaro (Brazil) “Insights into scorpion venom peptides: A new naturally occurring bioactive pentapeptide has resulted from the alternative processing of β-KTx propeptide from Tityus serrulatus venom”
-
Deyanell Hernandez (Venezuela) “TCTX1 a Tityus caripitensis toxin with effect over NAV1.4 channels”
-
Anally Ribeiro da Silva Menegasso (Brazil) “Scorpion venomics: a new analytical approach to study neglected peptides”
|
SESSION # 17: TOXINS AND PAIN
Room 2
Chairs:
1- Yara Cury (Brazil)
2- Richard J. Lewis (Australia)
Speakers:
-
Richard J. Lewis (Australia) “Analgesic c-conopeptides”
-
Gisele Piccolo (Brazil) “Interaction of the cannabinoid and opioid systems in the modulatin of antinociception induced by crotalphine”
-
Priscilla Galante (Brazil) “Identification and antinociceptive effect of the protonectin isolated from social wasp venom Parachartergus fraternus”
-
Bruna Luiza Emerich Magalhães (Brazil) “Antinociceptive effect of PNTX4(6-1), a peptide isolated from the venom of the armed spider Phoneutria nigriventer (Keyserling, 1891)”
-
Wilson Alves Ferretra Júnior (Brazil) “Involviment of 5-HT3 and TRPV1 receptors in the analgesic effect of BDS 391 on capsaicin-evoked thermal hyperlgesia”
|
SESSION # 18: TOXIN GENOMICS
Room 3
Chairs:
1- Paulo Lee Ho (Brazil)
2- Juan Calvete (Spain)
Speakers:
-
Juan Calvete (Spain) “Omic and structural studies evidence two clades of independently evolving short-sized disintegrins”
-
Matheus F. Fernandes Pedrosa (Brazil) “Profiling the venom gland of the scorpion Tityus stigmurus through a transcriptomic survey: new peptides potentially applicable in pharmaceutical research and biotechnology”
-
André Junqueira Zaharenko (Brazil) “Occurrence of deduced nucleotide sequences of inhibitory Cystine Knot (Ick) peptides in sea anemones identified by a 454 pyrosequencing approach”
-
Naoko Oda-Ueda (Japan) “The transcript catalogue for the venom gland of ProtoBothrops flavoviridis snake in Amami-Oshima, Japan”
-
Alba Fabiola C. Torres (Brazil) “cDNA library of venom apparatus from the giant ant Dinoponera quadriceps”
|
13h30
14h30 |
CONFERENCE #7
UNDERSTANDING LOCAL TISSUE PATHOLOGY INDUCED BY SNAKE VENOMS: UNSOLVED ISSUES
Chair: Catarina Texeira (Brazil)
Speaker: Jose Maria Gutierrez (Costa Rica) |
|
|
14h30
15h00 |
COFFEE BREAK |
15h00
17h00 |
SESSION # 19: SNAKE TOXINS
Room 1
Chairs:
1- Ana Maria Moura da Silva (Brazil)
2- Heloisa Selistre de Araújo (Brazil)
Speakers:
-
Ana Maria Moura da Silva (Brazil) “Diversity of snake venom metalloproteinases targeting hemostasis: an adaptive advantage for Viper snakes with consequences for human pathology”
-
Heloisa Selistre de Araújo (Brazil) “RGD disintegrins and the effects of v3 integrin blockade in the tumor microenvironment”
-
Danielle Paixão Cavalcante (Brazil) “New insights in the mechanisms by which African adders’ venoms cause pathology”
-
Michaela Sieber (Germany) “Membrane modifying properties of Crotamine, a small peptide-toxin from Crotalus durissus terifficus venom”
-
Eliecer de Jesus Jimenez Charris (Colombia) ‘Functional and proteomic characterization of the Eyelash Palm Pit-Viper (Bothriechis schlegelii) venom from Colombian south-west population”
|
SESSION # 20: ARTHROPOD TOXINS
Room 2
Chairs:
1- Maria Elena de Lima (Brazil)
2- Denise V. Tambourgi (Brazil)
Speakers:
-
Maria Elena de Lima (Brazil) “Spider toxins: exploring new peptides to possible drug models”
-
Oukkache Noual (Marrocos) “Comparison of the neurotoxic and myotoxic effects of tow moroccan scorpions venoms and their neutralization by an experimental polyclonal antivenom”
-
Denise V. Tambourgi (Brazil) “Venom of the Brazilian spider Sicarius ornatus (Araneae, Sicariidae) contains active Sphingomyelinase D: potential for toxicity after envenomation”
-
Thomaz A. Rocha e Silva (Brazil) “VdTX-1, a reversible nicotinic receptor antagonist isolated from venom of the spider Vitalius dubius (Theraphosidae)”
-
Luis Fernando Díaz Peña (Mexico) “Structural and functional characterization of Indian tarantula venom Poecilotheria regalis”
|
SESSION # 21: ENVENOMATION AND THERAPEUTICS
Room 2
Chairs:
1- Vidal Haddad Junior (Brazil)
2- David Warrell (UK)
Speakers:
-
Vidal Haddad Junior (Brazil) “Stings of freshwater stingrays as a real neglected problem in North, Midwest and Southeast regions of Brazil”
-
David Warrell (UK) “Challenges in the management of envenoming in developing countries”
-
Fábio Tozzi (Brazil) “Assistance to riverside communities in the Amazon and its implications for snakebites” (CANCELED)
-
Abdulrazaq Garba Habib (Nigeria) “Effect of distance and delay in access to care on outcome of snakebite in Nigeria”
-
Angel Anne Yanagihara (USA) “Cubozoan venom-induced cardiovascular collapse is caused by hyperkalemia and prevented by zinc gluconate in mice”
|
17h00
19h00 |
Poster session 3 |
20h00 |
Gala Dinner |
|
|
NOVEMBER 8th, 2013 |
|
Room 1 |
08h40
09h30 |
CONFERENCE #8
WHAT CAN TOXINS PROVIDE FOR DRUG DISCOVERY
Chair: Yara Cury (Brazil)
Speaker: Alan Harvey (UK) |
10h00
12h00 |
SESSION # 22: INITIATIVES IN TOXINOLOGY
Chairs:
1- Osvaldo Sant’Anna (Brazil)
2- Alan Harvey (UK)
Speakers:
-
Osvaldo Sant’Anna (Brazil) “Five years of the National Institute of Science and Technology on Toxins [INCTTOX]”
-
Hugo Harmelin (Brazil) “Toxins and Cell Signaling Networks”
-
Carlos Alvarez (Cuba) “Iberoamerican Network BIOTOX “
-
Abdulrazaq G. Habiib (Nigeria) “Initiatives for snakebite management in sub-Saharan Africa: The EchiTab study Group (Nigeria-UK)”
-
David Warrel (UK) “The Global Snakebite Initiative”
- Marcus V.G. Lacerda (Brazil) “ROdA: network of snakebite and scorpionism from Amazonia”
|
12h00
14h00 |
Celebrating 25 years of SBTx
Chair: Lea Simioni (Brazil)
Speaker: Julia Prado Franceschi (Brazil) |
|
CLOSING SESSION AND AWARDS |
|
|
|
|
|
|